Congrats on your new guitar. I also have a Fat Strat (Squier tho) and when I get a bit bored with bluesy or folksy songs, I flip the humbucker on and switch the amp to overdrive for some fun (driving the family and the dogs out of the living room at the same time....Bonus!).....

The tone change between the single coils is definate but very subtle (to my ear anyway) and that last switch to the humbucker is much more significant.

GG