I would say. A heavier string would require more effort. You generally get a fuller tone and better sustain with a heavier string, but a little harder to play. They are also better if you tune down, like to Eb; you'll be less susceptable to fret buzz because of the higher tension. A little harder on the neck. That's quite a heavy gauge imo, but I don't know what most folks play with. I use .009 - .042 on electric.

Interesting topic. I wonder what most folks use for there usual string gauge?