I had that problem in reverse awhile back. I was playing thru a digitech rp200a, and using one of my presets.... the problem with it was it sounded too processed and digital... it was like I was playing a keyboard or synth.... it bothered me so much because I really wanted to change the tone by how I played... like make a difference between plucking and picking... etc..

I've started to just play thru amps more often (when not in the metal kingdom), and it fixed my problem.