Hi ibanezMan90,

Generally speaking, an overdriven rock guitar uses humbucker pickups while blues guitars use single coils like Stevie Ray Vaughn or humbuckers like B.B. King.
For a rock sound you're gonna crank the gain and lower the master while blues is the opposite, lower the gain and crank the master for just a little bite and adjust the tone to your liking and for a bluesier tone try using the neck pickup. You're gonna hear more of the guitar's natural tone with a blues setting and I've noticed that the strat shaped Ibenez's I've played are really fast and a little thin sounding, getting more of the tone out of the electronics, so if you're looking for a bluesier tone and you're using one of these Ibanez's you might want to add a little more bass and mid to your tone setting.
Everyone will have different opinions on this but this is a good place to start.

Neal
=:D