A few key effects for me back when were a Dunlop Wah and a Boss Turbo Overdrive. Wah on all the time and all the way down (for a bit of compression). Weird but it worked. If I put the Boss before the Wah, it sounded choked but if I put it after the Wah, I had big tone. None of it was a 'by the books' kind of deal. Just playing until I got the sound I wanted.
Mess with whatever combo you like until you get the sound you want, that's the key. Just don't do something to blow it up!!