I've been playing lefty for 5 years now, and don't buy into the playing righthanded nonsense! I tried that and it doesn't feel right at all... the worst part of playing left handed is that the guitars are harder to find, and definately in a more limited selection; the other problem I've ran into is that either your friends always need to bring their ax over to the house, or you need to keep a spare righty around, which is what I did. Other than that, it isn't very much different, except to reverse in your head written instructions regarding left and right handed techniques. As somebody already brought up Jimmy, Kurt Cobaine was also a lefty! Other than that, it is almost the same exact thing. The only thing we lefty's have mastered doing right handed is using a cpu mouse; other than that, writing, throwing, playing hockey, among other things, we just have to develop on our own. Good luck! BTW, we need to start a forum for lefthanded guitar swaps/sales only! That would be really smart, I think...