I'm a Strat lover; have 1 1984 American, 1 1996 Made in Mexico (a/k/a Mim), and 1 2006 MiM- they all have their own unique sound and feel. My American has a maple neck, and the others have rosewood.

Bottom line is- test drive a bunch. The one that feels and sounds the best to you is the one. Everyone that might respond may have a different opinion, and, in the end, you wont be any further in deciding.

I agree with wildmann somewhat- for your basic American Strat you'll spend about $800; for a MiM, around $400. I tried a deluxe model (think that one cost $5-$600), made in Mexico, and it sounded as good as my 1984 American.

In general, I think Fender puts out a good guitar no matter where it was made. I'm willing to bet if you went on Ebay and set your limit at $300, you'd find a Strat where you'd be happy. My 2 MiMs were bought from Ebay, and each cost me just about $300. Both great guitars. I know I could sell either for a profit. So let your hands and ears be your guides. I test drove nearly every new model Srat earlier in the year- all good in their own way, but I couldn't find any major differences to justify spending double the price just because it was an American. Good luck in your search and welcome to GT!