I've seen a lot of right handed people start setting up their guitars like hendrix or other weird ways for no real reason. Sometimes it's just more natural for people. It is not really "better" but it lets them get going faster even if they would have been fine the conventional way, it just may have taken them a bit longer to get used to it.
I know thats why I set up my drum set the way I do. I am right handed but I play the bass with my left foot, and put the hi-hat on my right foot on my right side. The toms and snare are pretty much were they normally are.
It was just more natural for me, when I started I really had no clue so I just moved stuff around till it felt right. I think this is what everyone should do really, no matter what instrument. I mean obviously there are restrictions with some instruments and I am not really sure if the way I set up my drum set is going to come back to haunt me when I get better but I doubt it. Of course now when I go to play other peoples drums it is a little hard but whatever, I can still play it it's just a bit weird.