I'm left-handed, but I play guitar right-handed. I figure it's because I learnt on my dad's guitar, and he plays right handed, so that was just the way to go.

Strangely enough, my dad is also left-handed, and I have no idea why he plays right-handed. I guess it's a comfort thing; I feel like I have more control over my dominant hand.

When I was just starting out, I actually tried switching, because I thought being a lefty guitarist would make me stand out more (I was also a pretty huge Nirvana and Hendrix fan at the time, and you know how kids are with imitating their heroes). But it just didn't feel right at all, so I gave that up and went back to how it felt right.

I'm sure there are right-handers who play left-handed, though. There must be.