of course, it greatly depends on the guitar and the amp you're using. are you using any external effects like distortion? those often have their own tone controls and can really affect the sound. maybe you should try a small EQ, like a Boss footpedal or something. I have a Fender ultimate chorus, and i set my lows at 10, mids at 3, and highs at 9. but i run my guitar through a Boss metal zone combined with the overdrive on the amp, and combining two distortions is really hard to work with because of the buzz and tone control, but for some reason it works for me. exactly what fender amp do you have?