I second the Ibanez Prestige (the 2008 model above looks particularly tastey) and also nominate the Ibanez Jem models (they come either loaded with Breeds or Evolution pups).
If its purely speed and shred you are looking at, check out the soon to be released Dean RC7G - Rusty Cooley's new signature model. It has a massive cut away and the lower horn is one of the few that actually gives total and easy access to the 24th fret (you won't get that on Ibanez or Jackson guitars). Comes with a Floyd TRS trem (Floyds are good but the Ibanez Edge Pro trem on the Jems and some Prestige's is superior IMO), 7 strings, 25.5" scale, massive Dunlop 6000 jumbo frets, no tone control, just volume and two EMG 707 active pups. You can get them for a street price of about $1800 too - absolutely killer graphics on them too.