I'd suggest you take a look at the Eminence Patriot and Red Coat series before spending a ridiculous amount on Celestion speakers. I used to have 2 Eminence Wizards and 2 Governors in my Marshall 4x12 cab. That was a very nice combination. I ran 16ohm speakers, and the cab was wired so that it could be run 4 ohm mono, 16 ohm mono, or 8 ohm stereo. Whether it's wired series or parallel won't have an effect on the tone in the least bit. The different wiring just allows you to change the load.