Take Drop C tuning for example: Strings Low to High = C-G-C-F-A-D. This tuning creates an interval pattern of a 5th, 4th, 4th, 3rd and 4th. These altered interval patterns make many scale patterns have to be altered by their original fingering placement by intervals, created from standard tuning.
The Whole tone scale is ideal because it is a 6 tone scale of which any note can play as the tonic. There are basically only two scales you can create with it. One will contain the notes F-G-A-B-C#-D# and the other will contain the notes F#-G#-A#-C-D-E.
Another scale you can experiment with are the Harmonic minor/Major scales.
Good luck..............