I just put a set of Rotosound Yellows (.10 to .46) on my guitar today - I haven't plugged in with them yet, but they certainly feel great for intense leads - you can really dig into them for bending and vibrato, and you can whack them harder than you can ultralights without them twanging excessively. If it's speed you're after, it's like Grizz said - you can rip on any gauge of string if you practice enough with them.