Can someone tell me a consistent equation or hypothesis for tuning regarding the best combination of strings (manufacturer, type, and thickness) with the use of a nut locking device (if there is a technical name for this device, please bear with me) for an Ibanez GRG-170DX?

I'm stumped!! I have an electronic tuner and it's a nice one integral to a pedal system built by Digitech. The problem is I have this combination of light strings coupled with the use of a light pick and a tuning equation other than LOW to HIGH E to acquire consistent tuning. Whewww!!

Anyway, if there is a thread somewhere else here where I can study this situation with an added post to perhaps relate to this problem, it would be greatly appreciated.

Thanks!!!