what is good is a compressor if you have one. and also a gate.
the compressor is helps the tone. and the gate shuts out unwanted products of distortion.
for my epiphone les paul guitar i use the bridge pickup. and use the messa boogy dual rectifier amp on my line 6. i turn drive/overdrive to 10, base to /7 middle 4, treble 8.5, presence 10. no reverb. and an delay thing. only a slight one.
thats what i do