I can use my trem quite heavily and not have problems running out of tune. I don't have sustain or tone concerns. Forgiving my possible ignorance of your setup, if you're running a serious signal chain with effects and (mostly) distortion, how much of the resultant tone to you think is down to the guitar anyway?
You should talk to James Tyler or Tom Anderson - they'll make you a guitar exactly like you want, and be able to advise on the tonal properties of certain build combinations...
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