As long as you use the line outputs you should be ok. With anything that adds distortion or unusual cabinet simulations, be careful of using too much volume. You'll need an adapter if you want to use both the left and right outputs ( two 1/4" male to one 1/4" female). You can probably get away with just one output (it might even default to a mono signal if only one cord is plugged in), but sometimes you'll get a weird sound outa things like chorus or reverbs if you're only using one output of a stereo signal.