They don't 'get in the way' as such, but there are things to bear in mind - as you say, palm muting is different/difficult because if you rest your palm too hard you end up pushing everything out of tune, but it's just getting used to using the right amount of pressure.
Breaking strings is a drag, so you need a backup if you're playing live unless you're very brave. String bending double-stops need thought because when you bend one string the others change in pitch. Changing strings can be a drag, but you can wedge a shim under the bridge to hold it up while you change the string... as long as you don't change them all at once it's not too bad. And while re-stringing is a drag, once you get it in tune it'll stay there for ages....
There are loads of 'superstrats' with fixed bridges... what is it you like about the DXMG? Are the EMGs good for you?
Also, is this a first guitar? No offence, but if it is I'd avoid the FR trems until you have a little experience generally. If not, ignore me.... :D
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