No, the words "Fender" and "Distortion" generally dont go well together at all, especially with a strat (or any other single coil equipped guitar, for that matter). Single coils just don't cut it for distortion, they sound very thin & nasal in comparison w/ a humbucker (through ditortion), and they put out that super-annoying 60 hz hum. As for the amp, you're not going to get a good distortion out of it alone since it's primarily intended for sparkling clen sounds, but if you find a good multi effects pedal (or even an average one, given the amp sounds exellent clean) or distortion pedal, you can eq in a great, clear, high gain tone. If you're going to play a Strat through distortion, you need to put a humbucker in the bridge, though. Try a Duncan Custom (SH-5), it's a superb pickup.