I guess anything is possible. It would risk making a muddy bottom to the mix, but ya never know 'til ya try.
My model for bass tone is Mel Schacker of Grand Funk. My least favourite bass sound is the soft, mushy tone exemplified by the early Santana albums. Great bass lines that disappear when anyone else is playing! My favourite player to learn style from is John Paul Jones of Led Zeppelin.
I'm Olde-Skool, y'know? :D