Im not really sure what you mean by compatible with other pedals. You can use whatever pedal you want, just only the Line 6 pedals plug directly into it I believe. I use a Morley Bad Horsie 2 wah pedal and a DigiTech RP100 effects processor with it.
You can get many different tones out of it. It comes with a lot of different presets that you can tweak. Should easily be able to keep up with a drummer.
I highly recommend it.
Dont shoot yourself in the head.