I'm anal about my guitar's "health" and so after every session of playing, i take a rag and clean the strings, wipe down the fretboard, and then clean the fingerprints off of the body. Also, don't do what I made the mistake of doing, and walk around with your guitar strapped to your body. My old guitar got pretty thrashed up from doing that. I have a small personal studio, and whenever i'd start messing with some controls, the guitar would swing around and hit amps, my mixer, or a table leg or something and I got some pretty good size dents in it. Finally, if it's an electric, I highly recomend a locking guitar strap, because most other ones will pop off eventually for no apparent reason, and that'll leave you with some good marks on your axe. Hope it helps...