lose one drummer, and lose one guitarist..

rhythm guitarist will be in Drop D or Db, and will play some barred power chords utilizing palm muting alot, for example:

D|--0--0--6--5--0--0--0--0--3--2--5--6---------
A|--0--0--6--5--0--0--0--0--3--2--5--6---------
D|--0--0--6--5--0--0--0--0--3--2--5--6---------
Palm mute-------|---------|

while lead player plays one and two string riffs, so using the same key, he might play something like:

D|------3-2-3-6-------------3--
A|--0-0---------6-5-5-3-2-6----

or something like that..

bass player will just be playing along in key, and drummer will be playing with the bass drum alot.. perhaps even double bass if that's the kind of sound you're going for.

I really don't know what else to tell you, you just gotta experiment around.. but I've never heard of a successful band that had two drummers except for slipknot, but as far as I know, the two drummers don't play at the same time. so seriously, you don't want two drummers, and though it would be possible to have three guitarists, it isn't exactly easy to coordinate things between the three, it's better with one or two.