well, Stratocasters aren't really made for high, high distorition playing. Alot of your descriptions seems as if you got the right pups, they would sounds brash on a stratocaster. But rather than the guitar, amp's make a world of difference. Since what you said is so in detail, a tube amp would be the best choice. Yet they are known to make one's wallet skinny... The tubes produce such rich and full sound when on distortion which seens to be your niche. A transitor amp would make it either sounds real muddy and deep or real high and sqeaky.