It sounds like its really snapping the strings so he's most likely using a medium->hard pick. Yes the different pickups will have a big impact on the sound.
Set the EQ on your amp with ( out of 10 )..High 7-8, Mid 5-6, Bass 7-8.
The amp is being overdriven even with his first setting. This could be the work of the amp itself ( with the volume high ) or the work of the compressor. You'll need a tube amp to re-create this sound, because solid states do not act this way.
Electric Guitars are the inspiration for cries of "Turn that damn thing down"-Gibson website