Amp settings? I'm not exactly sure what you mean. Do you mean amp settings in conjunction with a Digitech pedal or amp settings in general without the use of an fx pedal? I dont know either way...when i use my Digitech pedal I set my amp to a clean tone and let my Digitech pedal do the rest of the work as far as amp settings and effects and reverbs and such. I use the RP100 which has over 1000 patches in the patch library at the moment. I absoultely love it...I got mine about 2 years ago for 60 bucks and I had never intended to use it for this long. I kinda thought I'd use it until I could afford some seperate pedals. When I finally could get some single effects pedals I just didnt like it. Hope that answers ur question.