I went the multi-effects route there for a while, but ended up comming back to real pedals. I played the Digitech, Boss, and Line6 stuff, and while they are all more convenient and more versatile, I still prefer the actual pedals. It's all in what sounds good to you, and that's all that matters. If a Zoom POS, I mean 505 or whatever, is what get's you your dream tone, then by all means use it. If you need a full rack system with midi controller's and all to get the tone you crave, then by all means use it. Tone is a very personal thing, and only you can decide what's right for you.

That being said, I do miss some of those crazy cool effects you get with the multi's, but I try to keep it simple these days with a wah, chorus, delay, reverb, and overdrive.