Im not sure, the major key doesnt really have a really blues feel to it, if you use a minor key it wont sound right and it'll be off. I play a lot of blues and I had the same problem, so I learned to play in the maj key. hendrix used alot of the maj mode ex. bold as love, castles made of sand, play these songs, they might be able to help you get a feel of it.
I am Comfortably Numb... :D
Oh yeah...STICK IT TO THE MAN!