Mid: 0
Bass: 7
OD: 10 (....OD stands for OverDrive.)
I have a strat with three single coils, and I mainly use the middle and bridge pickups. It should look like this: ____/__. The settings above are good for Metal and Hard Rock. For a nice clean sound I'd go like this:
Treb: 7 Tone control on strat: 10
Mid: 4
Bass: 5
OD: 0
Rev: 6 (....Rev stands for Reverb)
Good luck! I hope this helped you out a bit. :D