The blues scale stays constant throughout the whole 12-bar blues, but the mixolydian scale needs to change when the chord changes.
ex. - if A7 is the I, then you would use A blues scale, and A mixolydian
but on D7 - use A blues scale, but D mixolydian.
You can find the mixolydian scale in my modes tutorial on my instructor's page. (link on my signature).
There are only two important things in life - There's music and theres girls, not necessarily in that order....
The Ace's Guitar Tricks
The Ace's Guitar Tricks