1.Jimi Hendrix (most influencial)
2.Joe Satriani (started the virtuoso movement)
3.Slash (brought the blues to hard rock)
4.Mark Tremonti (Most overlooked guitar player in recent years. PS, I hate Creed... the guy can shred)
5.Jimmy Page (How many classic riffs has he come up with?)
Honorable Mention:
Kirk Hammett, Joe Perry, Stevie Ray Vaughan, Eric Clapton, Steve Vai, Jeff Beck, Kieth Richards, Randy Rhoads, Zakk Wylde, Mike Mcready,... the list could go on